“As “The Skeleton Twins” deftly glides between drama and comedy, it peels away layers of personal history in the lives of its troubled main characters, twin siblings estranged for a decade who share an eerie emotional synchronicity. At the very moment Maggie Dean (Kristen Wiig), a dental hygienist in upstate New York, is about to gulp a lethal fistful of sleeping pills, she receives a call informing her that her brother, Milo (Bill Hader), a failed actor in Hollywood, is in the hospital after slashing his wrists…. The movie, directed by Craig Johnson (the tiny indie “True Adolescents”) from a screenplay he wrote with Mark Heyman (a writer on “Black Swan”), is keenly attuned to the bonds of siblings, especially twins. If countless movies about brothers and sisters reveal common family traits, “The Skeleton Twins” is subtler than most in evoking a mutual sympathy that might be called a cellular understanding…. The movie transcends its mopey tendencies when the twins dress up hilariously for Halloween. And when Milo lip-syncs and cavorts to the Starship’s ’80s rock anthem “Nothing’s Gonna to Stop Us Now,” “The Skeleton Twins” soars deliriously into comic orbit.”—Stephen Holden, NY Times. R. 93 Min.